Best Mushrooms for Anxiety (and Depression)

anxiety depression Mar 31, 2025

In the U.S., approximately 19.1% of adults experience an anxiety disorder each year, while 7.1% face major depressive disorder. Globally, over 260 million people struggle with anxiety, and 280 million live with depression. While conventional treatments like therapy and medication are effective for many, more people are seeking natural remedies to complement their care. One option gaining attention is medicinal mushrooms.

Mushrooms have been used for thousands of years in traditional medicine for their healing properties. Today, modern research is shedding light on how certain mushrooms can help manage anxiety and depression. Let’s explore the best mushrooms for anxiety and depression, their benefits, and how they work.

1. Reishi (Ganoderma lucidum)

Reishi, also known as the mushroom of immortality, has been a staple in Traditional Chinese Medicine for centuries. Once reserved for royalty, this adaptogenic mushroom helps the body regulate stress and promote relaxation.

How It Helps: Reishi contains triterpenes, naturally sedative compounds that calm the nervous system. These compounds work to reduce cortisol and adrenaline levels, two stress hormones that can contribute to anxiety. Reishi also has antioxidant properties, which combat oxidative stress—a known factor in both anxiety and depression.
How to Take It: Due to its tough texture and bitter taste, reishi is best consumed as an extract, tea, or supplement.

2. Lion’s Mane (Hericium erinaceus)

Lion’s mane is a white, globe-shaped mushroom with long, shaggy spines. Though commonly used in cooking, it’s also praised for its potential benefits for brain health.

How It Helps: Chronic inflammation is a key factor in anxiety and depression. Lion’s mane has strong anti-inflammatory properties that can help reduce these symptoms. Studies show it may promote nerve cell growth and repair, improving the function of the hippocampus—a brain region involved in memory and emotional regulation. This may help explain why lion’s mane has been shown to alleviate mild anxiety and depression in animal studies.
How to Take It: Lion’s mane is available as capsules, powders, and extracts. You can also find it in culinary form, though it has a slightly bitter taste.

3. Cordyceps (Cordyceps sinensis)

Cordyceps is an adaptogenic mushroom known for its energy-boosting and anti-inflammatory properties. It has been used for centuries to enhance physical stamina and reduce fatigue.

How It Helps: Chronic inflammation in the brain can impair emotional regulation and memory, leading to anxiety and depression. Cordyceps helps reduce this inflammation and supports the production of key proteins involved in mood regulation. Early research suggests it may have antidepressant effects, providing a natural option for those looking to improve their mental well-being.
How to Take It: Cordyceps is often available in supplement form, including powders, capsules, and extracts.

4. Chaga (Inonotus obliquus)

Chaga is a dark, woody mushroom that grows on birch trees throughout the northern hemisphere. Known as an antioxidant powerhouse, chaga has been used in traditional medicine in Russia, China, and Japan for centuries.

How It Helps: Chaga’s high antioxidant content helps combat oxidative stress, which can lead to anxiety and depression. By supporting a healthy stress response and improving cognitive function, chaga may enhance memory, focus, and overall mental health.
How to Take It: Chaga is commonly consumed as a tea or extract. Its earthy flavor makes it a comforting addition to your daily routine.

Why Mushrooms Are Worth Considering

Mushrooms offer a unique combination of adaptogenic, anti-inflammatory, and neuroprotective properties that can support both mental and physical health. While more research is needed, early studies suggest that medicinal mushrooms can complement traditional treatments for anxiety and depression. They provide a holistic approach by targeting inflammation, stress hormones, and brain health—all key factors in emotional well-being.

How to Get Started

Before adding medicinal mushrooms to your routine, it’s important to consult with a healthcare professional familiar with natural remedies. This is especially true if you’re taking medications or managing an ongoing condition. They can help you determine the right dosage and form, ensuring that the mushrooms you choose align with your overall health goals.

If you’re curious about how mushrooms and other natural therapies can support your mental health, our naturopathic practice specializes in women’s hormonal and emotional well-being. Reach out to us to learn more about how we can help you thrive.